Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The DNA Helix01:07

The DNA Helix

22.0K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
22.0K
DNA as a Genetic Template02:05

DNA as a Genetic Template

22.5K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
22.5K
Structures of Solids02:22

Structures of Solids

14.5K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
14.5K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

21.3K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
21.3K
Newman Projections02:06

Newman Projections

17.3K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
17.3K
Polytene Chromosomes02:04

Polytene Chromosomes

10.2K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperativity, entropy, and effective concentration in DNA origami self-replication.

Science advances·2026
Same author

A tunable autonomous RNA-fueled micro-engine.

Nature communications·2026
Same author

Blunt-force assembly of programmable DNA architectures using π-π stacking.

Nature communications·2026
Same author

Acoustic separation and isolation of viruses, small extracellular vesicles and other nanoscale bioparticles.

Nature protocols·2026
Same author

Dynamic Control of DNA Origami Self-Assembly by Transcriptional Modules.

Journal of the American Chemical Society·2026
Same author

DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Aug 31, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.8K

The wending rhombus: Self-assembling 3D DNA crystals.

Brandon Lu1, Simon Vecchioni1, Yoel P Ohayon1

  • 1Department of Chemistry, New York University, New York, New York.

Biophysical Journal
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

Recent advances in self-assembling three-dimensional (3D) DNA crystals showcase diverse macromolecular motifs. Future directions explore noncanonical base pairing for novel nanodevices and materials engineering applications.

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.5K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.4K

Related Experiment Videos

Last Updated: Aug 31, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.8K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.5K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.4K

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Materials Science

Background:

  • Self-assembling three-dimensional (3D) DNA crystals represent a rapidly evolving field.
  • Early work focused on basic structural motifs, with significant progress in expanding structural diversity.

Purpose of the Study:

  • To summarize recent developments in 3D DNA crystal self-assembly.
  • To explore future directions, including noncanonical base pairing.
  • To survey current and future applications in nanodevices and materials engineering.

Main Methods:

  • Review of advancements in DNA crystal structure formation.
  • Analysis of self-assembly strategies.
  • Comparison with DNA origami techniques.

Main Results:

  • Increased diversity of macromolecular crystal motifs through self-assembly.
  • Emerging applications in reversibly active nanodevices.
  • Progress in materials engineering using DNA crystals.

Conclusions:

  • 3D DNA crystals offer unique structural possibilities beyond traditional methods.
  • Exploitation of noncanonical base pairing will drive future innovation.
  • Synergies between 3D DNA crystals and DNA origami can enhance biomolecule structure determination and nanotechnology.