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Proteoglycans01:05

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Updated: Aug 31, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Plant Polysaccharides in Engineered Pharmaceutical Gels.

Juliana O Bahú1, Lucas R Melo de Andrade2, Raquel de Melo Barbosa3

  • 1National Institute of Science and Technology in Biofabrication (INCT-BIOFABRIS), School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, Campinas 13083-852, SP, Brazil.

Bioengineering (Basel, Switzerland)
|August 25, 2022
PubMed
Summary

Plant-derived polysaccharide gels offer sustainable, biocompatible solutions for drug delivery. Their natural properties enable controlled release and antimicrobial effects, supporting the circular economy in biomedical applications.

Keywords:
absorbentbio-baseddrug deliverygumshydrogelslignocellulosicscaffolds

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmacology

Background:

  • Hydrogels are crucial in pharmaceuticals and biomedicine due to their absorbent properties and ability to encapsulate bioactive agents for controlled release.
  • Plant-derived polysaccharides form biocompatible hydrogels mimicking the extracellular matrix, offering biodegradability and antimicrobial effects.
  • These plant-based biogels align with circular economy principles, providing a low-cost, sustainable material source.

Purpose of the Study:

  • To review plant-derived polysaccharide gels as viable materials for biomedical applications, particularly in controlled drug release.
  • To explore the sources, biological functions, extraction methods, and properties of these natural hydrogels.
  • To highlight their potential in health-related fields due to their biocompatibility and functional characteristics.

Main Methods:

  • Literature review of plant-derived polysaccharide hydrogels.
  • Analysis of extraction techniques for polysaccharides from various plant sources.
  • Evaluation of hydrogel properties, including biocompatibility, biodegradability, and antimicrobial activity.
  • Assessment of applications in controlled drug delivery and contact with the human body.

Main Results:

  • Plant polysaccharides like cellulose, pectin, and gums can be processed into hydrogels with tunable properties.
  • These hydrogels exhibit excellent biocompatibility, biodegradability, and inherent antimicrobial activity.
  • Sustainable sourcing and low production costs make these biogels economically attractive.
  • Demonstrated potential for incorporating drugs for effective, controlled release in biomedical settings.

Conclusions:

  • Plant-derived polysaccharide hydrogels represent a promising class of biomaterials for pharmaceutical and biomedical applications.
  • Their sustainable origin, biocompatibility, and functional properties support their use in drug delivery systems.
  • Further research into extraction and application methods can unlock the full potential of these natural hydrogels in healthcare.