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Total Internal Reflection Ellipsometry Approach for Bloch Surface Waves Biosensing Applications.

Ernesta Bužavaitė-Vertelienė1, Vincentas Maciulis1, Justina Anulytė1

  • 1State Research Institute Center for Physical Sciences and Technology, Saulėtekio Ave. 3, LT-10257 Vilnius, Lithuania.

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|August 25, 2022
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Summary
This summary is machine-generated.

This study demonstrates enhanced protein detection sensitivity using a one-dimensional photonic crystal with a TiO2 layer, leveraging Bloch surface waves (BSW). The BSW approach significantly boosts signal detection for biosensing applications.

Keywords:
Bloch surface wavesbiosensingbovine serum albumintotal internal reflection ellipsometry

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Area of Science:

  • Optoelectronics
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Photonic crystals (PCs) are engineered materials with unique optical properties.
  • Bloch surface waves (BSW) offer enhanced light-matter interaction at surfaces.
  • TiO2 layers can modify optical responses and improve sensor performance.

Purpose of the Study:

  • To investigate the enhanced signal sensitivity of a 1D photonic crystal with a TiO2 layer for protein interaction detection.
  • To compare the optical response of BSW and PC configurations.
  • To evaluate the potential of BSW excitations for advanced biosensing.

Main Methods:

  • Fabrication of a 1D photonic crystal with an integrated TiO2 layer.
  • Utilizing BSW excitation for optical measurements.
  • Employing a model system of bovine serum albumin and antibodies for protein interaction studies.
  • Analyzing ellipsometric parameters (Ψ and Δ) to quantify sensitivity.

Main Results:

  • The 1D PC with a TiO2 layer demonstrated enhanced sensitivity for both p- and s-BSW components.
  • The BSW component of p-polarization showed a significant sensitivity increase.
  • Sensitivity of the Ψ parameter was five times higher, and the Δ parameter was eight times higher compared to the PC sample without the TiO2 layer.

Conclusions:

  • The addition of a TiO2 layer to a 1D photonic crystal significantly enhances BSW sensitivity for biosensing.
  • BSW excitations provide a powerful platform for designing highly sensitive biosensors.
  • This approach holds promise for advanced protein interaction detection and other biomedical applications.