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Related Experiment Video

Updated: Aug 31, 2025

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites

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Reactive Species-Activatable AIEgens for Biomedical Applications.

Xiaoying Kang¹, Yue Li¹, Shuai Yin¹

¹State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.

|August 25, 2022

Summary

Aggregation-induced emission luminogens (AIEgens) offer advanced optical probes for detecting reactive species. This review details AIE-based strategies for early disease diagnosis and therapy, focusing on cancer and inflammatory conditions.

Keywords:

activatable probe afterglow aggregation-induced emission bioimaging fluorescence photoacoustic reactive oxygen nitrogen species theranostics

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Area of Science:

Biomedical Optics
Materials Science
Chemical Biology

Background:

Precision medicine demands sensitive diagnostics with high spatiotemporal resolution.
Early detection of endogenous biomarkers is crucial for timely diagnosis and treatment.
Aggregation-induced emission luminogens (AIEgens) are promising optical agents for biomedical applications.

Purpose of the Study:

To review recent advances in AIE-based probes for reactive species detection.
To summarize molecular design strategies for enhanced probe performance.
To discuss theranostic applications of AIE probes in major diseases.

Main Methods:

Literature review of AIE-based probes for reactive species detection.
Analysis of molecular design strategies for sensitivity and wavelength tuning.
Compilation of theranostic applications in cancer, inflammation, and vascular diseases.

Main Results:

AIEgens show significant promise as optical agents for detecting reactive species (ROS, RNS, RSS, RCS).
Molecular design strategies can enhance probe sensitivity, tune response wavelengths, and enable afterglow imaging.
AIE-based probes are being explored for theranostic applications in major diseases.

Conclusions:

AIE-based probes represent a powerful tool for disease diagnostics and therapeutics.
Further research into specifically activatable AIE systems can advance clinical translation.
Understanding structure-property-application relationships is key for designing effective AIE agents.