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Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery.

Maria Tannous1,2, Silvia Lucia Appleton2, Gjylije Hoti2

  • 1Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.

Gels (Basel, Switzerland)
|August 25, 2022
PubMed
Summary

New dextrin-based nanohydrogels were developed for topical rokitamycin delivery. These swellable carriers demonstrate sustained drug release at skin pH, showing promise for macrolide antibiotic applications.

Keywords:
cyclodextrinformulationlinecapsnanohydrogelsnanospongesrokitamycin

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Area of Science:

  • Pharmaceutical Nanotechnology
  • Drug Delivery Systems
  • Macrolide Antibiotics

Background:

  • Macrolides are broad-spectrum antibiotics requiring effective drug delivery systems.
  • Topical delivery of macrolides is crucial for treating specific infections, including those caused by Acanthamoeba.

Purpose of the Study:

  • To develop novel, swellable, dextrin-based nanohydrogels for topical rokitamycin delivery.
  • To characterize the nanohydrogels' properties, including swelling, mucoadhesion, and drug loading capacity.
  • To evaluate the in vitro drug release kinetics of rokitamycin from the nanohydrogels.

Main Methods:

  • Preparation of nanohydrogels using cross-linked β-cyclodextrin (β-CD) or Linecaps® (LC) as building blocks.
  • Formulation of aqueous nanosuspensions and incorporation of rokitamycin.
  • Characterization of nanohydrogel size, surface charge, swelling degree, and mucoadhesion.
  • In vitro drug release studies at different pH levels.

Main Results:

  • Dextrin-based nanohydrogels (β-CD and LC) exhibited high swelling and mucoadhesion.
  • Rokitamycin-loaded nanohydrogels had an average size of ~200 nm and negative surface charge.
  • Sustained and controlled in vitro release of rokitamycin was observed at skin pH, suggesting pH responsiveness.

Conclusions:

  • Developed dextrin-based nanohydrogels are effective carriers for topical rokitamycin delivery.
  • The nanohydrogels' properties support sustained drug release, beneficial for topical applications.
  • This platform holds potential for the topical delivery of other macrolide antibiotics.