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Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue
Daniela Filip1, Doina Macocinschi1, Mirela-Fernanda Zaltariov2
1Laboratory of Physical Chemistry of Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, Romania.
Gels (Basel, Switzerland)
|August 25, 2022
Summary
New hydrogel blends of hydroxypropyl cellulose (HPC) and Pluronic F68 show promise for tissue engineering. These materials offer good mechanical strength and biocompatibility, with tunable properties for specific applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Hydrogels are crucial for tissue engineering scaffolds due to their similarity to natural extracellular matrices.
- Designing hydrogels with specific properties for tissue repair and cellular support remains a significant challenge.
- Polymeric blends offer a route to tailor hydrogel characteristics for enhanced functionality.
Purpose of the Study:
- To investigate hydroxypropyl cellulose (HPC)/Pluronic F68 hydrogel blends for tissue scaffold applications.
- To elucidate the individual contributions of HPC and Pluronic F68 to the blend's properties.
- To assess the potential of these blends in tissue repair and drug delivery systems.
Main Methods:
- Fourier-transform infrared (FTIR) and 1H nuclear magnetic resonance (1HNMR) spectroscopies for interaction analysis.
- Scanning electron microscopy (SEM) and dynamic vapor sorption (DVS) for porosity and moisture behavior.
- Biodegradability studies in simulated biological media.
- Mucoadhesion tests on small intestine mucosa and biocompatibility assays on NHDF cell lines.
Main Results:
- HPC component significantly influenced BET/GAB areas, monolayer values, and mucoadhesivity.
- Pluronic F68 component enhanced thermal stability and contributed to cell membrane repair potential.
- All blends exhibited good mechanical strength and enhanced biocompatibility with NHDF cells.
- The blends demonstrated tunable properties based on composition, with notable mucoadhesion.
Conclusions:
- Hydrogel blend composition critically determines scaffold behavior and functionality.
- HPC/Pluronic F68 blends show potential for tissue repair, particularly for damaged cell membranes.
- These polymeric blends are promising candidates for controlled intestinal drug delivery formulations.
