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Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men.
Jani P Vaara1, Heikki Kyröläinen2, Tommi Vasankari3,4
1Department of Leadership and Military Pedagogy, National Defence University, 00861 Helsinki, Finland.
Metabolites
|August 25, 2022
Summary
Sedentary time (SB) and physical activity (PA) are linked to distinct metabolic pathways. This study found significant associations between sedentary behavior and specific metabolites, offering insights into energy production and lipid metabolism.
Area of Science:
- Metabolomics
- Exercise Physiology
- Biochemistry
Background:
- Physical activity (PA) offers numerous health benefits, yet the underlying metabolic mechanisms are not fully understood.
- Metabolome-wide association studies (MWAS) can elucidate the intricate relationship between PA and metabolic pathways.
- Limited research exists on the association between accelerometer-measured sedentary time (SB) and PA with comprehensive metabolomic profiles.
Purpose of the Study:
- To investigate the association between accelerometer-measured sedentary time (SB) and physical activity (PA) with serum metabolomic measures in young adult men.
- To identify specific metabolic pathways influenced by sedentary behavior and different intensities of physical activity.
- To explore potential mechanistic links between SB, PA, and metabolic health outcomes.
Main Methods:
- Utilized accelerometer data to quantify sedentary time (SB) and physical activity (PA) in 314 young adult men.
- Analyzed 66 serum metabolites using nuclear magnetic resonance (NMR)-based metabolomics from fasting samples.
- Employed regression analysis, including both single and compositional approaches, to assess associations between SB/PA and metabolites.
Main Results:
- Compositional analysis identified 4 significantly associated (p ≤ 0.002) and 13 trend-significant (p < 0.05) metabolomic variables with sedentary time (SB).
- Observed trend-significant associations (p < 0.05) between moderate-to-vigorous PA and 5 metabolites, and light-intensity PA with 1 metabolite.
- Key associations involved metabolic pathways related to ketone bodies and amino acid concentrations, suggesting impacts on energy production and lipid metabolism.
Conclusions:
- Sedentary time (SB) is significantly associated with alterations in specific metabolic pathways, including those involving ketone bodies and amino acids.
- Physical activity, particularly moderate-to-vigorous intensity, shows trends towards association with distinct metabolic profiles.
- These findings provide mechanistic insights into how sedentary behavior and physical activity influence energy production and lipid metabolism, relevant to health outcomes.
