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Twenty-Four-Hour Central Hemodynamic Load in Adults With and Without a History of COVID-19
Andrew R Heckel1, Danielle M Arcidiacono1, Kailee A Coonan1
1Syracuse University, Syracuse, New York, USA.
Insights
COVID-19 recovery does not appear to significantly alter 24-hour blood pressure metrics. This study found no increased central hemodynamic load in adults recovering from mild-to-moderate Coronavirus Disease 2019.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Hypertension is a known risk factor for severe Coronavirus Disease 2019 (COVID-19).
- Limited understanding exists regarding COVID-19's impact on blood pressure (BP).
- Central BP monitoring via ambulatory blood pressure monitoring (ABPM) offers prognostic value for cardiovascular disease (CVD) risk assessment.
Purpose of the Study:
- To assess cardiovascular disease (CVD) risk in adults with and without a history of COVID-19.
- To evaluate 24-hour brachial and central hemodynamic load using ABPM in post-COVID-19 adults.
- To determine if COVID-19 infection affects central blood pressure measures.
Main Methods:
- Cross-sectional analysis of 32 adults with a history of COVID-19 and 43 controls.
- Utilized 24-hour ambulatory blood pressure monitoring (ABPM) to measure hemodynamic load.
- Assessed parameters including central and brachial systolic/diastolic BP, augmentation index (AIx), and pulse wave velocity (PWV).
Main Results:
- Participants with COVID-19 history experienced mild-to-moderate illness with an average of 6 symptoms.
- Evaluations occurred 122 ± 123 days post-COVID-19 diagnosis.
- No significant differences were found in 24-hour, daytime, or nighttime central or peripheral hemodynamic load between groups.
Conclusions:
- Adults recovering from mild-to-moderate COVID-19 show no significant differences in 24-hour brachial or central ABPM measures compared to controls.
- Recovery from mild-to-moderate COVID-19 does not lead to increased 24-hour central hemodynamic load.
Background:
Although hypertension is a risk factor for severe Coronavirus Disease 2019 (COVID-19) illness, little is known about the effects of COVID-19 on blood pressure (BP). Central BP measures taken over a 24-hour period using ambulatory blood pressure monitoring (ABPM) adds prognostic value in assessing cardiovascular disease (CVD) risk compared with brachial BP measures from a single time point. We assessed CVD risk between adults with and without a history of COVID-19 via appraisal of 24-hour brachial and central hemodynamic load from ABPM.
Methods:
Cross-sectional analysis was performed on 32 adults who tested positive for COVID-19 (29 ± 13 years, 22 females) and 43 controls (28 ± 12 years, 26 females). Measures of 24-hour hemodynamic load included brachial and central systolic and diastolic BP, pulse pressure, augmentation index (AIx), pulse wave velocity (PWV), nocturnal BP dipping, the ambulatory arterial stiffness index (AASI), and the blood pressure variability ratio (BPVR).
Results:
Participants who tested positive for COVID-19 experienced 6 ± 4 COVID-19 symptoms, were studied 122 ± 123 days after testing positive, and had mild-to-moderate COVID-19 illness. The results from independent samples t-tests showed no significant differences in 24-hour, daytime, or nighttime measures of central or peripheral hemodynamic load across those with and without a history of COVID-19 (P > 0.05 for all).
Conclusions:
No differences in 24-hour brachial or central ABPM measures were detected between adults recovering from mild-to-moderate COVID-19 and controls without a history of COVID-19. Adults recovering from mild-to-moderate COVID-19 do not have increased 24-hour central hemodynamic load.
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