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[DNA interaction with the bifunctional acridine dye].

E B Moroshkina, T F Stepanova, V V Raketskaia

    Molekuliarnaia Biologiia
    |March 1, 1987
    PubMed
    Summary

    DNA-complexes with acridines were studied. Both mono- and diacridines bind to DNA via intercalation, with diacridine

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    [Protein profile strain specificity of Bifidobacterium genus members].

    Zhurnal mikrobiologii, epidemiologii i immunobiologii·2015

    Area of Science:

    • Molecular Biology
    • Biochemistry
    • Structural Biology

    Context:

    • DNA-acridine interactions are crucial for understanding drug-DNA binding.
    • Acridine derivatives are known DNA intercalators.
    • Ionic strength significantly influences molecular interactions.

    Purpose:

    • To comparatively study DNA complex formation with mono- and diacridines.
    • To elucidate the binding modes of diacridines with DNA at varying ionic strengths and concentrations.
    • To assess the impact of these ligands on DNA molecular parameters.

    Summary:

    • Both mono- and diacridines intercalate into DNA regardless of ionic strength.
    • At low ionic strength (0.001), diacridine binding transitions from bis-intercalation to mono-intercalation as concentration increases, causing DNA structural changes.
    • At higher ionic strength (0.1), diacridines act as mono-intercalators, similar to mono-acridines.

    Impact:

    • Reveals concentration-dependent binding modes of diacridines with DNA.
    • Demonstrates the influence of ionic strength on DNA-ligand complexation.
    • Provides insights into the structural consequences of DNA intercalation by acridine derivatives.

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