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IODINE-125 PLAQUE BRACHYTHERAPY FOR DIFFUSE CHOROIDAL HEMANGIOMA.
Corrina P Azarcon1, Richard L J Qiu2, Ethan K Sobol1
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.
Retinal Cases & Brief Reports
|August 25, 2022
Summary
Iodine-125 plaque radiotherapy effectively treated diffuse choroidal hemangioma in children, leading to tumor regression. While generally safe, potential radiation-induced complications exist.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Pediatric Oncology
Background:
- Diffuse choroidal hemangioma is a rare, benign vascular tumor.
- Treatment options for pediatric diffuse choroidal hemangioma are limited.
- Brachytherapy offers a localized radiation approach.
Purpose of the Study:
- To evaluate the efficacy and safety of iodine-125 plaque brachytherapy for diffuse choroidal hemangioma in children.
- To report outcomes in a cohort of pediatric patients treated at a single center.
Main Methods:
- Retrospective case series design.
- Six pediatric patients with diffuse choroidal hemangioma were treated.
- Iodine-125 radioactive plaque delivered 34.2-42.1 Gy to the tumor apex over a median of 4 days.
Main Results:
- All patients showed tumor regression and subretinal fluid resolution within 17 months.
- Visual acuity improved in two patients.
- Complications included radiation-induced cataract, subretinal fibrosis, and radiation retinopathy in one patient each. No neovascular glaucoma developed.
Conclusions:
- Iodine-125 plaque radiotherapy is an effective treatment for pediatric diffuse choroidal hemangioma.
- The treatment carries a risk of radiation-induced complications that require monitoring.
