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Updated: Aug 31, 2025

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study
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How gene duplication diversifies the landscape of protein oligomeric state and function

Saurav Mallik1, Dan S Tawfik2, Emmanuel D Levy3

  • 1Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 7610001, Israel.

Current Opinion in Genetics & Development
|August 25, 2022
PubMed
Summary

Gene duplication in oligomeric proteins drives evolution. This review explores how duplicated genes diversify protein structures and functions, leading to new cellular innovations.

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