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Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.

E Murugan1, C R Akshata1, R Ilangovan2

  • 1Department of Physical Chemistry, School of Chemical Sciences University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.

Colloids and Surfaces. B, Biointerfaces
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

Quaternized chitosan-hydroxyapatite composites enhance curcumin delivery for bone regeneration. Modified chitosan improves solubility and mineralization, showing potential for tissue engineering applications.

Keywords:
ChitosanCurcuminHAPQuaternization

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery

Background:

  • Chitosan's poor aqueous solubility limits its use in biomedical applications.
  • Hydroxyapatite (HAP) is crucial for bone regeneration.
  • Developing effective drug delivery systems for bone defects is essential.

Purpose of the Study:

  • To improve chitosan solubility via quaternization for HAP composite fabrication.
  • To evaluate quaternized chitosan-HAP composites as curcumin delivery vehicles for bone regeneration.
  • To investigate the effect of quaternization degree on composite properties and bioactivity.

Main Methods:

  • Chitosan was modified by quaternization to create low (LQC) and high (HQC) quaternized forms.
  • In situ HAP growth was facilitated by modified chitosan at alkaline pH, forming LQC-HAP and HQC-HAP composites.
  • Curcumin was loaded into the composites (LQC-HAP-C, HQC-HAP-C) and characterized.
  • In vitro studies using MG-63 cells assessed biocompatibility, proliferation, and calcium mineralization.

Main Results:

  • Quaternization significantly improved chitosan's aqueous solubility and facilitated HAP growth.
  • Drug encapsulation efficiency increased 2.6-fold with quaternization.
  • Curcumin-loaded composites demonstrated biocompatibility, enhanced cell proliferation, and a 2-fold increase in calcium mineralization.
  • Mechanical strength slightly decreased, while drug release increased with quaternization.

Conclusions:

  • Quaternized chitosan-HAP composites offer tailorable physicochemical properties for drug delivery.
  • The degree of quaternization influences drug loading, release kinetics, and bioactivity.
  • These composites show significant promise as advanced drug delivery systems for bone regeneration applications.