Research progress of m⁶A regulation during animal growth and development

Environmental factors, genetic factors, and epigenetics are involved in animal growth and development. Among them, methylation is one of the abundant modifications of epigenetics. N6-methyladenosine(m⁶A) is extensive in cellular RNA, of which mRNA is the most common internal modification. m⁶A modification regulates life activities dynamically and reversibly, including expressed genes, RNA metabolism, and protein translation. The m⁶A modifications are closely related to human diseases involving heart failure, tumors, and cancer. It is relatively in-depth in the medical field. However, there are few studies on its biochemical function in animals. We summarized the latest paper related to the chemical structure and role of the writers, the erasers, and the readers to study exerting dynamic regulation of m⁶A modification of animal growth and development. Furthermore, the key roles of m⁶A modification were reported in the process of RNA metabolism. Finally, the dynamic regulation of m⁶A modification in animal growth and development was reviewed, including brain development, fertility, fat deposition, and muscle production. It reveals the key roles of m⁶A modification and the regulation of gene expression, aiming to provide new ideas for m⁶A methylation in animal growth and development.