Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

259
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
259
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

491
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
491
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

422
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
422
Seizures: Classification01:13

Seizures: Classification

563
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
563
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

569
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
569

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula.

Epilepsia·2025
Same author

Ictal Involvement of the Pulvinar and the Anterior Nucleus of the Thalamus in Patients With Refractory Epilepsy.

Neurology·2024
Same author

Semiautomated Detection of Early Infarct Signs on Noncontrast CT Improves Interrater Agreement.

Stroke·2023
Same author

Bone marrow stromal cells increase oligodendrogenesis after stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2009
Same author

Critical roles of voltage-dependent sodium channels in the process of synaptogenesis during the postnatal cortical development of rats.

Cellular and molecular neurobiology·2009
Same author

Phase I study of repeated intraepithelial delivery of adenoviral p53 in patients with dysplastic oral leukoplakia.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2009
Same journal

Artificial intelligence-driven multi-omics analysis of gut-kidney axis in chronic kidney disease.

Progress in molecular biology and translational science·2026
Same journal

Artificial intelligence in multi-omics analysis of heart diseases.

Progress in molecular biology and translational science·2026
Same journal

AI in multi-omics analysis of type 2 diabetes.

Progress in molecular biology and translational science·2026
Same journal

AI in multi-omics analysis in AMR.

Progress in molecular biology and translational science·2026
Same journal

AI in multi-omics analysis of COVID-19 patient data.

Progress in molecular biology and translational science·2026
Same journal

AI in multi-omics analysis of liver diseases.

Progress in molecular biology and translational science·2026
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.8K

Precision medicine in epilepsy.

Ryan James McGinn1, Erica Leah Von Stein1, Jacqueline Elizabeth Summers Stromberg1

  • 1Department of Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.

Progress in Molecular Biology and Translational Science
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

Precision medicine offers tailored epilepsy treatments by leveraging genetic testing and personalized therapies, improving outcomes for patients with recurrent seizures. This approach enhances diagnosis, prognosis, and management of comorbidities.

Keywords:
EpilepsyGeneticsNeuromodulationPharmacogeneticsPrecision medicine

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

20.5K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.5K

Related Experiment Videos

Last Updated: Aug 31, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.8K
Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

20.5K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.5K

Area of Science:

  • Neurology
  • Genetics
  • Pharmacogenomics

Background:

  • Epilepsy affects over 50 million globally, with one-third of patients unresponsive to current anti-seizure medications.
  • Treatment challenges arise from epilepsy's heterogeneity and variable patient responses.
  • A precision medicine approach, considering individual patient characteristics, is crucial for effective epilepsy management.

Purpose of the Study:

  • To summarize recent advances in genetic testing for epilepsy syndromes.
  • To review current personalized treatments, including pharmacogenomics and neuromodulation.
  • To discuss the future of large-scale precision medicine in epilepsy care.

Main Methods:

  • Review of recent genetic testing approaches in epilepsy.
  • Analysis of current precision therapies in pharmacogenomics.
  • Discussion of tailored neuromodulation treatments for epilepsy patients.

Main Results:

  • Over 30% of epilepsy syndromes have identified genetic components.
  • Personalized treatments are increasingly applicable to genetic epilepsy syndromes.
  • Precision medicine is advancing for targeted therapies, diagnosis, and prognosis.

Conclusions:

  • Genetic testing and personalized therapies are key to advancing precision medicine in epilepsy.
  • Pharmacogenomics and neuromodulation represent current precision treatment strategies.
  • Precision medicine holds promise for comprehensive epilepsy management, including comorbidities.