Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

488
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
488
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

908
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
908
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

435
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
435
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

211
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
211

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acceptability and accuracy of point-of-care monitoring of lithium levels.

The British journal of psychiatry : the journal of mental science·2026
Same author

High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Antipsychotic drug action, novel treatment targets, and the failure of current clinical trial designs in evaluating new target molecules.

Biological psychiatry·2026
Same author

Redox dysregulation, inflammation and mental health in adults with high risk of childhood maltreatment.

European child & adolescent psychiatry·2026
Same author

Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data.

PLoS medicine·2026
Same author

Academic psychiatry: a key research asset is shrinking.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Microbiota-gut-brain axis in autism spectrum disorder: integrating brain structure, function, and transcriptomics.

Translational psychiatry·2026
Same journal

Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.

Translational psychiatry·2026
Same journal

Maraviroc attenuates inflammation-exacerbated cognitive and amyloid pathology in an early-stage Alzheimer's disease mouse model.

Translational psychiatry·2026
Same journal

High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Translational psychiatry·2026
Same journal

Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.

Translational psychiatry·2026
Same journal

DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli.

Translational psychiatry·2026
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K

Hippocampal circuit dysfunction in psychosis.

Samuel Knight1, Robert McCutcheon2, Daniella Dwir3

  • 1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. samuel.knight@kcl.ac.uk.

Translational Psychiatry
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

The hippocampus, crucial for brain development, shows vulnerability in psychosis. Targeting hippocampal dysfunction may offer new ways to prevent or delay psychosis onset, moving beyond current dopamine-focused treatments.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.4K

Related Experiment Videos

Last Updated: Aug 31, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Current psychosis treatments focus on dopamine receptor antagonism after diagnosis, offering limited efficacy and side effects.
  • These treatments fail to address negative/cognitive symptoms and lack preventive capabilities.
  • Emerging research highlights the hippocampus's role in psychosis pathophysiology due to its neurodevelopmental origins.

Purpose of the Study:

  • To review evidence on hippocampal vulnerability in psychosis.
  • To explore mechanisms of hippocampal dysfunction in psychosis and at-risk individuals.
  • To discuss potential therapeutic strategies targeting the hippocampus for psychosis prevention.

Main Methods:

  • Literature review synthesizing recent data on hippocampal neurodevelopment and function in psychosis.
  • Examination of structural and functional imbalances, metabolic pressures, and oxidative stress in the hippocampus.
  • Analysis of mechanisms underlying hippocampal dysfunction in psychosis.

Main Results:

  • The hippocampus exhibits neurodevelopmental susceptibility to dysfunction, including structural/functional imbalances and metabolic/oxidative stress.
  • Hippocampal abnormalities are implicated in both diagnosed psychosis and individuals at high risk.
  • These abnormalities present potential targets for early intervention.

Conclusions:

  • The hippocampus is a key area vulnerable in the neurodevelopmental trajectory of psychosis.
  • Targeting hippocampal circuit imbalances offers a promising avenue for novel preventive therapies.
  • Future research should focus on prospective studies to validate hippocampal-based interventions for psychosis.