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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms

Gui-Nv Hu1, Yan Wang2, Chih-Hsin Tang3,4,5

  • 1Department of Surgical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

Scientific Reports
|August 25, 2022
PubMed

Insights

Genetic variations in angiopoietin-2 (ANGPT2) single nucleotide polymorphisms (SNPs) may influence breast cancer risk and progression. Certain ANGPT2 SNPs and a specific haplotype were associated with altered breast cancer susceptibility and lymph node involvement in Chinese Han women.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Breast cancer remains a significant global health concern, necessitating further research into its genetic underpinnings.
  • While anti-angiogenesis therapies are explored, the role of angiopoietin-2 (ANGPT2) single nucleotide polymorphisms (SNPs) in breast cancer subtypes is not well understood.

Purpose of the Study:

  • To investigate the association between ANGPT2 SNPs and breast cancer susceptibility in a Chinese Han population.
  • To explore the impact of ANGPT2 polymorphisms on breast cancer progression, including lymph node status and specific subtypes like HER2-enriched disease.

Main Methods:

  • A case-control study involving 464 breast cancer patients and 539 cancer-free controls.
  • Genotyping of five ANGPT2 SNPs (rs2442598, rs734701, rs1823375, 11,137,037, and rs12674822) using TaqMan technology.
  • Haplotype analysis was performed to assess combined SNP effects on breast cancer risk.

Main Results:

  • The GG allele of rs1823375 was associated with a reduced likelihood of clinically staged breast cancer diagnosis.
  • In HER2-enriched breast cancer, specific genotypes (CG or CG+GG) at rs1823375 correlated with lower lymph node metastasis (N1-N3).
  • The ANGPT2 T-T-C-A-T haplotype significantly increased the risk of developing malignant breast neoplasms by 1.385-fold.

Conclusions:

  • This study provides the first evidence linking ANGPT2 polymorphisms to breast cancer development and progression in Chinese Han females.
  • ANGPT2 SNPs may serve as potential genetic markers for breast cancer susceptibility and clinical outcomes.

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