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The crucial roles of long noncoding RNA SNHGs in lung cancer

Feng Chen1,2, Fa Zhang3, Yu-Fang Leng4

  • 1Department of Anesthesiology, First Hospital of Lanzhou University, 1 Donggang West Road, Chengguan District, Lanzhou, 730000, Gansu, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 25, 2022
PubMed

Insights

Long non-coding RNAs (lncRNAs), specifically small nucleolar RNA host genes, are linked to lung cancer

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer presents a significant global health challenge with high morbidity and mortality.
  • Current lung cancer treatments, including surgery, radiotherapy, chemotherapy, and targeted therapy, remain suboptimal.
  • Understanding the molecular mechanisms underlying lung cancer is crucial for developing effective therapies.

Purpose of the Study:

  • To review the role of small nucleolar RNA host genes (lncRNA SNHGs) in lung cancer.
  • To highlight the association of lncRNA SNHGs with lung cancer's biological characteristics and therapeutic resistance.
  • To explore the potential of lncRNA SNHGs as diagnostic biomarkers for lung cancer.

Main Methods:

  • Literature review of studies investigating lncRNA SNHGs in lung cancer.
  • Analysis of research on the molecular mechanisms involving lncRNA SNHGs.
  • Examination of data regarding the diagnostic and therapeutic implications of lncRNA SNHGs.

Main Results:

  • lncRNA SNHGs are implicated in the biological behavior of lung cancer, including non-small cell lung cancer.
  • These genes are associated with resistance to various lung cancer treatments.
  • lncRNA SNHGs show promise as potential diagnostic biomarkers.

Conclusions:

  • lncRNA SNHGs play a critical role in lung cancer development and progression.
  • Further research is necessary to validate the clinical utility of lncRNA SNHGs in lung cancer diagnosis and treatment.
  • Targeting lncRNA SNHGs may offer novel therapeutic strategies for lung cancer.
Keywords:
Biological characteristicsLung cancerSmall nucleolar RNA host genesTherapeutic targetlncRNA

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