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Updated: Aug 31, 2025
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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
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Exploring Lead loci shared between schizophrenia and Cardiometabolic traits
Qian He1, Adam N Bennett1, Jundong Liu1
1Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, SAR, China.
BMC Genomics
|August 25, 2022
Summary
Schizophrenia (SCZ) patients face shorter lifespans due to cardiovascular issues. This study reveals shared genetic factors between SCZ and metabolic traits like body mass index, highlighting a complex biological interplay.
Area of Science:
- Genetics
- Psychiatry
- Cardiovascular Disease
Background:
- Individuals with schizophrenia (SCZ) experience significantly reduced life expectancy, largely attributed to cardiovascular disease comorbidity.
- Genome-wide association studies (GWAS) have identified genetic variants for SCZ and cardiometabolic traits separately, but shared genetic influences remain unclear.
Purpose of the Study:
- To investigate the genetic overlap between schizophrenia and cardiometabolic traits.
- To identify specific genetic variants and genes that jointly influence SCZ and cardiometabolic risk factors.
Main Methods:
- Utilized conditional false discovery rate (FDR) and local genetic correlation analyses.
- Employed conjunctional FDR to detect shared genetic traits between SCZ and cardiometabolic risk factors.
Main Results:
- Identified 144 genetic variants shared between SCZ and body mass index (BMI), and 15 variants shared between SCZ and triglycerides (TG).
- Discovered four novel single nucleotide polymorphisms (SNPs) and four proximate genes (DERL2, SNX4, LY75, EFCAB6) common to SCZ and BMI.
- Highlighted rs13307 and LY75 as potentially influencing SCZ and BMI comorbidity, with observed bidirectional genetic associations.
Conclusions:
- Demonstrated a significant genetic overlap between schizophrenia and cardiometabolic traits.
- Suggested a complex interplay involving metabolism-related gene pathways in the pathophysiology of schizophrenia.
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