Related Experiment Video
Updated: Aug 31, 2025
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Tumor-Promoting ATAD2 and Its Preclinical Challenges
Haicheng Liu1,2, Qianghai Wen1,2, Sheng Yan1,2
1Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Abstract:
ATAD2 has received extensive attention in recent years as one prospective oncogene with tumor-promoting features in many malignancies. ATAD2 is a highly conserved bromodomain family protein that exerts its biological functions by mainly AAA ATPase and bromodomain. ATAD2 acts as an epigenetic decoder and transcription factor or co-activator, which is engaged in cellular activities, such as transcriptional regulation, DNA replication, and protein modification. ATAD2 has been reported to be highly expressed in a variety of human malignancies, including gastrointestinal malignancies, reproductive malignancies, urological malignancies, lung cancer, and other types of malignancies. ATAD2 is involved in the activation of multiple oncogenic signaling pathways and is closely associated with tumorigenesis, progression, chemoresistance, and poor prognosis, but the oncogenic mechanisms vary in different cancer types. Moreover, the direct targeting of ATAD2's bromodomain may be a very challenging task. In this review, we summarized the role of ATAD2 in various types of malignancies and pointed out the pharmacological direction.
Insights
The ATAD2 gene, a cancer-promoting oncogene, plays a key role in various malignancies. This review explores ATAD2
Area of Science:
- Molecular oncology
- Epigenetics
- Cancer biology
Background:
- The ATAD2 gene is recognized as a potential oncogene implicated in tumor promotion across numerous cancers.
- ATAD2 is a conserved protein featuring AAA ATPase and bromodomain functionalities, crucial for its biological roles.
Purpose of the Study:
- To review the multifaceted role of ATAD2 in diverse human malignancies.
- To identify potential pharmacological strategies targeting ATAD2.
- To elucidate ATAD2's involvement in tumorigenesis, cancer progression, and therapeutic resistance.
Main Methods:
- Comprehensive literature review on ATAD2's function and expression in various cancers.
- Analysis of ATAD2's involvement in epigenetic regulation and oncogenic signaling pathways.
- Examination of ATAD2's association with clinical outcomes and treatment resistance.
Main Results:
- ATAD2 is highly expressed in gastrointestinal, reproductive, urological, and lung cancers, among others.
- ATAD2 contributes to oncogenesis, progression, and chemoresistance by activating signaling pathways.
- Targeting ATAD2's bromodomain presents significant challenges.
Conclusions:
- ATAD2 is a critical oncogene across multiple cancer types, with varying mechanisms of action.
- Understanding ATAD2's oncogenic roles is essential for developing targeted therapies.
- Further research into novel pharmacological approaches is warranted.
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:27Tumor Immunotherapy