Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

Area of Science:

• Endocrinology
• Dermatology
• Metabolic Research

Background:

• Irisin, an adipo-myokine from muscle and fat, influences various bodily processes.
• Limited research exists on serum irisin in psoriatic patients.
• Psoriasis is a chronic inflammatory skin condition with systemic implications.

Purpose of the Study:

• To investigate serum irisin levels in chronic plaque psoriasis patients.
• To compare irisin levels between psoriatic patients and healthy controls.
• To determine the correlation between serum irisin and psoriasis severity (PASI score).

Main Methods:

• Competitive enzyme-linked immunosorbent assay (ELISA) for serum irisin quantification.
• Inclusion of 46 chronic plaque psoriasis patients and 46 matched controls.
• Assessment of psoriasis severity using the Psoriasis Area and Severity Index (PASI).

Main Results:

• Serum irisin concentrations were non-significantly elevated in psoriatic patients versus controls.
• A negative non-linear correlation was observed between PASI scores and serum irisin levels.
• The inverse relationship between irisin and PASI was more pronounced in patients with mild psoriasis.

Conclusions:

• Serum irisin levels do not significantly differ between psoriasis patients and controls.
• Irisin exhibits a negative association with psoriasis severity, especially in mild cases.
• Further research is warranted to elucidate irisin's precise role in psoriasis pathogenesis.