Citrate regional anticoagulation in haemodialysis

Area of Science:

• Nephrology
• Hematology

Background:

• Systemic anticoagulation poses risks for certain hemodialysis patients.
• Citrate offers a localized anticoagulation alternative.

Purpose of the Study:

• To evaluate the safety and efficacy of a simple citrate anticoagulation procedure in hemodialysis.
• To measure plasma citrate levels in patients undergoing regular dialysis.

Main Methods:

• A technically simple procedure using small volumes of citrate solution was trialed.
• Plasma citrate levels were measured.
• Whole blood clotting times were assessed using pre- and post-dialyzer samples.

Main Results:

• The procedure effectively restricted anticoagulation to the extracorporeal circulation.
• Plasma citrate levels were successfully monitored.
• Whole blood clotting times confirmed localized anticoagulation.

Conclusions:

• Citrate anticoagulation is a safe and acceptable option for hemodialysis patients at risk.
• The procedure is technically simple and effective for localized anticoagulation.