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Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with
Aobo Chen1,2, Chenglong Cao1,2,3, Bangxin Liu2
1The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
Brain Sciences
|August 26, 2022
Summary
Pituitary adenoma patients show cognitive deficits, including slower reaction times and impaired attention and conflict monitoring. Elevated prolactin levels may contribute to this cognitive decline.
Area of Science:
- Neuroscience
- Endocrinology
- Cognitive Psychology
Background:
- Pituitary adenomas (PAs) are increasingly linked to cognitive impairment.
- Hyperprolactinemia and tumor mass effect are suspected causes.
- Understanding cognitive deficits in PAs is crucial for patient care.
Purpose of the Study:
- To identify cognitive impairments in patients with prolactinomas.
- To investigate the correlation between cognitive indices and prolactin (PRL) levels, controlling for tumor size.
- To explore the neurophysiological underpinnings of cognitive dysfunction in PAs.
Main Methods:
- Utilized the flanker task with electroencephalography (EEG) recording.
- Compared 27 prolactinoma patients with 26 healthy controls (HC).
- Analyzed behavioral (reaction time) and event-related potential (ERP) data (P2, N2, P3 amplitudes).
Main Results:
- Patients exhibited slower reaction times (RTs) on the flanker task.
- Reduced P2 and enhanced N2 amplitudes indicated impaired attentional processing and conflict monitoring.
- Lower P3 amplitudes suggested deficits in attentional resource allocation.
- Significant correlation found between P3 amplitudes, RTs, and PRL levels in patients.
Conclusions:
- Prolactinomas are associated with significant cognitive impairments.
- Oversecreted prolactin (PRL) may exert cognitive toxicity.
- Findings provide evidence for further research into cognitive decline in PAs and the role of PRL.
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