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Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder
Sisi Zheng1,2, Nan Song1,2, Sici Wang1,2
1The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Brain Sciences
|August 26, 2022
Summary
This study identified new brain stimulation targets for depersonalization-derealization disorder (DPD) using neuroimaging. These findings may enhance non-invasive brain stimulation therapy for DPD patients.
Area of Science:
- Neuroscience
- Psychiatry
Background:
- Non-invasive brain stimulation (NIBS) shows promise for depersonalization-derealization disorder (DPD).
- Previous NIBS target sites for DPD were empirically determined.
- Functional magnetic resonance imaging (fMRI) can help identify optimal stimulation locations.
Purpose of the Study:
- To identify potential brain surface targets for non-invasive brain stimulation in DPD.
- To leverage neuroimaging techniques to improve NIBS efficacy in DPD.
Main Methods:
- Utilized three neuroimaging pipelines: ALE meta-analysis, functional connectivity analysis of the DPD-network, and functional connectivity analysis based on DPD regions of interest.
- Included data from five studies (36 foci) and 76 subjects for network analysis.
- Identified potential targets using 10-20 system coordinates for brain surface regions.
Main Results:
- Identified several potential brain surface stimulation sites for DPD.
- Key regions include bilateral medial prefrontal cortex, dorsal lateral prefrontal cortex, superior parietal gyrus, superior temporal gyrus, and right ventrolateral prefrontal cortex.
Conclusions:
- The identified brain regions represent potential targets for optimizing NIBS in DPD.
- These findings may guide clinicians in applying more effective non-invasive brain stimulation therapies for DPD.
