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Updated: Aug 31, 2025
14:39
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
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Effect of Polyphenolic Complements on Cognitive Function in the Elderly: A Systematic Review
María José Rodrigo-Gonzalo1,2, Susana González-Manzano1,2,3, Roberto Mendez-Sánchez2,3
1Grupo de Investigación de Polifenoles (GIP-USAL), Universidad de Salamanca, E-37007 Salamanca, Spain.
Antioxidants (Basel, Switzerland)
|August 26, 2022
Summary
Dietary polyphenols, including flavanols and stilbenes, show promise in improving cognitive function and counteracting neuroinflammation in individuals over 50. High doses and longer treatment durations appear most effective.
Area of Science:
- Nutritional Neuroscience
- Gerontology
- Pharmacology
Background:
- Polyphenols are known for their chronic disease benefits and potential cognitive effects.
- Neuroinflammation is a suspected mechanism underlying cognitive decline.
- Specific polyphenol subclasses like flavanols, flavonols, and stilbenes are of interest.
Purpose of the Study:
- To review nutritional interventions using polyphenol-rich foods or supplements.
- To assess the impact on cognitive deterioration in individuals over 50.
- To explore the role of flavanols, flavonols, and stilbenes in cognitive health.
Main Methods:
- Systematic review of clinical trials from PubMed and Web of Science (March 2010 - March 2020).
- Selection of 14 relevant studies.
- Assessment of cognitive function using cognitive tests and fMRI.
Main Results:
- All selected studies reported some cognitive improvement post-intervention.
- Flavanol and stilbene interventions showed significant benefits in both healthy and impaired individuals.
- High doses and longer treatment durations correlated with greater cognitive benefits.
Conclusions:
- Nutritional interventions with specific polyphenols can positively impact cognitive function in older adults.
- The choice of cognitive assessment tools is critical for evaluating intervention efficacy.
- Further research into optimal dosing and duration is warranted.
Keywords:
cognitive functioncognitive impairment and neurophysicological functionflavanolsflavonoidsstilbenesMore Related Videos
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