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The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function
Nora E Gray1, Marcelo Farina2, Paolo Tucci3
1Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA .
Biomedicines
|August 26, 2022
Summary
Nuclear factor (erythroid-derived 2)-like 2) (NRF2) activation protects the brain by reducing oxidative stress and inflammation. This review explores NRF2
Area of Science:
- Neuroscience
- Molecular Biology
- Pharmacology
Background:
- Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor regulating cellular defense mechanisms against oxidative stress.
- NRF2 influences antioxidant enzymes, mitochondrial function, and inflammatory responses, playing a crucial role in cellular homeostasis.
- Dysregulation of NRF2 is implicated in various neurodegenerative diseases, highlighting its importance in brain health.
Purpose of the Study:
- To review the evidence supporting NRF2 activation for cognitive enhancement and neuroprotection.
- To critically discuss the therapeutic potential of NRF2 activators in cognitive impairment.
Main Methods:
- In vitro studies
- In vivo studies
- Clinical trials
Main Results:
- NRF2 activation demonstrates a role in maintaining and improving cognitive function.
- Evidence suggests NRF2 activation can elicit neuroprotection and cognitive enhancement.
- NRF2 modulates antioxidant and anti-inflammatory pathways relevant to brain health.
Conclusions:
- NRF2 activation holds promise for neuroprotection and cognitive enhancement.
- NRF2 activators may offer prophylactic or therapeutic benefits for cognitive impairment.
- Further research into NRF2 modulation is warranted for neurological disorders.
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