Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of RNA01:23

Types of RNA

64.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
64.5K
RNA Interference01:23

RNA Interference

26.4K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.4K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

220
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
220
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.9K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.9K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Experimental RNAi02:15

Experimental RNAi

6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes.

Nature communications·2026
Same author

Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes.

Cell communication and signaling : CCS·2026
Same author

Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications.

International journal of molecular sciences·2025
Same author

A novel nested gene <i>Aff3ir</i> participates in vascular remodeling by enhancing endothelial cell differentiation in mice.

Genes & diseases·2025
Same author

Histone Deacetylase 7-Derived 7-Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration.

Journal of cellular and molecular medicine·2024
Same author

Unveiling impaired vascular function and cellular heterogeneity in diabetic donor-derived vascular organoids.

Stem cells (Dayton, Ohio)·2024

Related Experiment Video

Updated: Aug 30, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.7K

RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction.

Victoria A Cornelius1, Hojjat Naderi-Meshkin1, Sophia Kelaini1

  • 1Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Cells
|August 26, 2022
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cell (iPSC) technologies are revolutionizing vascular disease research. These models enhance our understanding of RNA-binding proteins (RBPs) and their therapeutic potential in cardiovascular conditions.

Keywords:
QKIQuakingRNA-binding proteinsiPSCsstem cell technologiesvascular disease

More Related Videos

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

11.2K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.6K

Related Experiment Videos

Last Updated: Aug 30, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.7K
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

11.2K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.6K

Area of Science:

  • Regenerative Medicine
  • Molecular Biology
  • Cardiovascular Science

Background:

  • Vascular diseases, particularly cardiovascular diseases, are a leading cause of global mortality.
  • Induced pluripotent stem cell (iPSC) technologies offer novel disease models for studying vascular health.
  • Understanding molecular mechanisms of vascular damage is crucial for developing effective treatments.

Purpose of the Study:

  • To explore the role of RNA-binding proteins (RBPs) in vascular dysfunction using iPSC models.
  • To investigate the therapeutic potential of RBPs in cardiovascular diseases.
  • To highlight the significance of the Quaking family of RBPs.

Main Methods:

  • Utilizing induced pluripotent stem cell (iPSC) technology to create disease-specific vascular models.
  • Analyzing transcriptional and post-transcriptional regulatory mechanisms.
  • Investigating the function of RNA-binding proteins (RBPs) in cellular processes.

Main Results:

  • iPSC models have advanced the understanding of molecular mechanisms in vascular diseases.
  • RNA-binding proteins (RBPs) play critical roles in gene expression and cellular functions relevant to vascular health.
  • Newly discovered roles of RBPs in the cardiovascular system are emerging.

Conclusions:

  • iPSC-based research is crucial for clarifying vascular disease mechanisms.
  • RNA-binding proteins (RBPs) represent promising therapeutic targets for cardiovascular diseases.
  • The Quaking family of RBPs warrants further investigation for therapeutic applications.