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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Aug 30, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells.

Jorge L Alió Del Barrio1,2, Ana De la Mata3,4,5, María P De Miguel6

  • 1Cornea, Cataract and Refractive Surgery Unit, Vissum (Miranza Group), 03016 Alicante, Spain.

Cells
|August 26, 2022
PubMed
Summary
This summary is machine-generated.

Adipose-derived stem cells offer a promising cell-free therapy for corneal regeneration. Their secretome, rich in regenerative factors, could revolutionize treatments for corneal diseases.

Keywords:
adipose-derived stem cellscellular therapycorneacorneal epitheliumcorneal regenerationcorneal stromacorneal transplantdecellularized corneaextracellular vesiclesmesenchymal stem cellsregenerative medicinestem cells

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Adipose-derived stem cells (ASCs) are multipotent stem cells easily harvested via minimally invasive procedures.
  • ASCs possess immunomodulatory properties and promote tissue regeneration through paracrine signaling via extracellular vesicles.
  • The ASC secretome is a potential source for cell-free regenerative therapies, reducing costs and regulatory hurdles.

Purpose of the Study:

  • To review preclinical and clinical evidence on ASCs for regenerating the human cornea.
  • To evaluate the potential of ASC secretome in cell-free corneal regenerative therapies.

Main Methods:

  • Review of existing preclinical studies on ASCs for corneal regeneration.
  • Analysis of human clinical trial data concerning ASC applications in ophthalmology.

Main Results:

  • ASCs demonstrate potential for regenerating corneal epithelium, stroma, and endothelium.
  • The paracrine action of ASC secretome shows promise for cell-free corneal repair.

Conclusions:

  • Adipose-derived stem cells and their secretome represent a viable strategy for corneal tissue regeneration.
  • Cell-free therapies using ASC secretome could broaden clinical applications in treating corneal pathologies.