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Published on: July 5, 2017
The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
Giuseppe Sirago1, Anna Picca2, Emiliana Giacomello3
1Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Abstract:
Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in individuals of different ages are currently unclear. Here, we provide a brief overview of relevant literature on the contribution of genetics to muscle disuse, retraining, and aging, and offer a perspective on unanswered questions on the subject that may open new venues for research.
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