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Related Experiment Videos

Delayed skin hypersensitivity reaction in normal children.

A A Kerr, R G Denton

    The New Zealand Medical Journal
    |July 26, 1978
    PubMed
    Summary
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    Cell-mediated immunity tests using common antigens are unreliable in children under three. Reactivity increases with age, reaching adult levels by 12-16 years, indicating test limitations in early childhood.

    Area of Science:

    • Immunology
    • Pediatrics
    • Cell-Mediated Immunity

    Background:

    • Delayed-type hypersensitivity (DTH) skin tests assess cell-mediated immunity.
    • Assessing DTH reactions is crucial for evaluating immune competence in children.

    Purpose of the Study:

    • To evaluate the reliability of DTH skin tests in normal children across different age groups.
    • To determine the age-related changes in DTH reactivity in pediatric populations.

    Main Methods:

    • Normal children were tested for delayed skin hypersensitivity.
    • Antigens used included Candida, purified protein derivative (PPD), and streptokinase/streptodornase.
    • Reactivity was assessed based on induration size at specific time points.

    Main Results:

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    • DTH reactivity was low in children under three years (20%).
    • Reactivity significantly increased in older children, reaching approximately 90% in the 12-16 year age group.
    • The observed reactivity pattern approximated adult immune responses in older children.

    Conclusions:

    • Standard DTH skin tests are considered unsatisfactory for assessing cell-mediated immunity in young children.
    • Age-dependent variations in DTH responses highlight the need for age-specific interpretation or alternative immune assessment methods in pediatric populations.