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Updated: Aug 30, 2025

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

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New Progress in Early Diagnosis of Atherosclerosis

Heyu Meng1,2,3, Jianjun Ruan1,2,3, Zhaohan Yan1,2,3

  • 1Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis, Jilin Provincial Cardiovascular Research Institute, Jilin University, Changchun 130033, China.

International Journal of Molecular Sciences
|August 26, 2022
PubMed

Insights

Early diagnosis of coronary atherosclerosis, a key cause of cardiovascular disease, can be improved using new methods in imaging, gene/protein markers, and trace elements for better patient outcomes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • Coronary atherosclerosis is a progressive circulatory condition and the primary cause of cardiovascular disease.
  • Cardiovascular events stem from thrombosis, platelet aggregation, and plaque rupture, with disease severity linked to coronary artery calcification.
  • Assessing calcification is crucial for diagnosing and managing coronary atherosclerosis.

Purpose of the Study:

  • To review recent advancements in the early diagnosis of coronary atherosclerosis.
  • To explore novel diagnostic approaches across imaging, genetic/protein markers, and trace elements.

Main Methods:

  • Literature review of recent studies on early coronary atherosclerosis diagnosis.
  • Analysis of new techniques in medical imaging for calcification assessment.
  • Evaluation of genetic, protein, and trace element biomarkers for early detection.

Main Results:

  • Emerging imaging techniques offer improved assessment of coronary artery calcification.
  • Novel gene and protein markers show potential for identifying early atherosclerotic changes.
  • Trace element analysis presents a new avenue for detecting early-stage atherosclerosis.

Conclusions:

  • Integrating advanced imaging, molecular markers, and trace element analysis can enhance early diagnosis of coronary atherosclerosis.
  • These advancements are vital for timely intervention and improved management of cardiovascular disease.
  • Further research is needed to validate these novel diagnostic methods in clinical practice.

Keywords:
computed tomography coronary angiographycoronary atherosclerosisgenesproteintrace element

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