Increase of in vitro brain [3H]muscimol binding after L-homocysteine administration to rat

L-Homocysteine intraperitoneal injections to the rat induced 50-70% inhibition of phosphatidyl-N-methyltransferase activity. A 30-40% increase of muscimol (a gamma-aminobutyric acid (GABA) agonist) binding was observed; Scatchard plot analysis showed an increase of the number of sites. [3H]Diazepam binding was not modified.