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Antibacterial Soy Protein Isolate Prepared by Quaternization.

Qi Dong1, Jingwen Lei1, Hanjian Wang1

  • 1Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease, TaiKang Medical School (School of Basic Medicine Sciences), Wuhan University, Wuhan 430071, China.

International Journal of Molecular Sciences
|August 26, 2022
PubMed
Summary

Quaternized soy protein isolate (QSPI) exhibits enhanced antibacterial properties and improved water solubility. This novel derivative shows potential for applications in industry and tissue engineering, promoting wound healing.

Keywords:
antibacterial propertyquaternizationsoy protein isolatewound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Materials Science

Background:

  • Soy protein isolate (SPI) is a versatile, eco-friendly protein with industrial and biomedical applications.
  • Enhancing the antibacterial properties of SPI is crucial for developing safer and more effective products.
  • Current applications of SPI could be expanded with improved functional characteristics.

Purpose of the Study:

  • To synthesize quaternized soy protein isolate (QSPI) with enhanced antibacterial properties.
  • To evaluate the antibacterial efficacy of QSPI in vitro and in vivo.
  • To assess the biocompatibility and wound healing potential of QSPI.

Main Methods:

  • QSPI was synthesized via the reaction of 2,3-epoxypropyltrimethylammonium chloride (EPTMAC) with SPI.
  • Antibacterial activity was tested against multiple bacterial strains in vitro and in vivo.
  • Biocompatibility and wound healing were assessed using rat models.
  • Water solubility of QSPI was analyzed across a broad pH range.

Main Results:

  • QSPI demonstrated significant positive surface charge (17.8 ± 0.23 mV) due to quaternary ammonium groups.
  • QSPI exhibited superior antibacterial properties against various bacteria.
  • QSPI maintained good biocompatibility and accelerated bacterial-infected wound healing in rats.
  • QSPI showed enhanced water solubility compared to native SPI across a wide pH spectrum.

Conclusions:

  • QSPI is a promising derivative of soy protein isolate with potent antibacterial activity.
  • The enhanced water solubility and biocompatibility of QSPI expand its application potential.
  • QSPI offers a versatile platform for developing advanced materials in industry and tissue engineering.