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The Omnipresence of DYRK1A in Human Diseases

Estelle Deboever1, Alessandra Fistrovich2,3, Christopher Hulme2,3

  • 1ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.

International Journal of Molecular Sciences
|August 26, 2022
PubMed

Insights

As the global population ages, novel therapeutic strategies are crucial for age-related diseases. This study explores the dual-specificity tyrosine-regulated kinase 1A (DYRK1A) as a promising therapeutic target for various human diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • The global population is aging, increasing the demand for effective treatments for age-related diseases.
  • Kinases are critical regulators of cellular processes and represent key targets for drug development.
  • The dual-specificity tyrosine-regulated kinase (DYRKs) family, particularly DYRK1A, is implicated in numerous human diseases.

Purpose of the Study:

  • To characterize the DYRK1A protein.
  • To elucidate the regulatory mechanisms of DYRK1A.
  • To review the functional role of DYRK1A in various human diseases and its therapeutic potential.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of DYRK1A's molecular characteristics.
  • Examination of DYRK1A's involvement in disease pathogenesis.

Main Results:

  • DYRK1A is a significant regulator with a broad impact on human health.
  • Dysregulation of DYRK1A is linked to diverse pathological conditions.
  • DYRK1A presents a promising target for the development of novel therapeutics.

Conclusions:

  • Understanding DYRK1A's characteristics and roles is vital for developing new treatments.
  • DYRK1A holds significant therapeutic promise for age-related and other human diseases.
  • Further research into DYRK1A is warranted to fully exploit its therapeutic potential.
Keywords:
DYRK1Acancersdiabetesheart diseasesneurodegenerative diseasesprotein kinaseviral infections

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