Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Changing Etiological Landscape of Liver Cancer in the Era of Metabolic Disease.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Human papillomavirus viral load as promising surrogate biomarker of cervical cancer risk and clinical outcome.

Expert review of molecular diagnostics·2026

Same author

Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy.

Immunity & ageing : I & A·2026

Same author

Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement.

Gut·2026

Same author

Differential Uptake and Release of Female Genital Secretions Components and HPV DNA by Veil, Swab, and Vaginal Tampon.

Diagnostics (Basel, Switzerland)·2026

Same author

Cannabidiol Regulates CD47 Expression and Apoptosis in Jurkat Leukemic Cells Dependent upon VDAC-1 Oligomerization.

Pharmaceuticals (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Aug 30, 2025

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Cannabinoids and Chronic Liver Diseases.

Ralph-Sydney Mboumba Bouassa^1,2, Giada Sebastiani^2,3,4, Vincenzo Di Marzo^5,6,7,8

¹Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada.

International Journal of Molecular Sciences

|August 26, 2022

Summary

Targeting the liver

Keywords:

ALD HCV HIV NAFLD NASH cannabidiol (CBD)cannabinoids chronic liver diseases endocannabinoid system insulin resistance steatosis tetrahydrocannabinol (THC)

More Related Videos

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Administration of Δ⁹-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

Related Experiment Videos

Last Updated: Aug 30, 2025

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Administration of Δ⁹-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

Area of Science:

Hepatology and Pharmacology
Endocannabinoid System Research

Background:

Chronic liver diseases (CLDs), including nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease (ALD), and viral hepatitis, are major global health concerns.
These diverse CLDs share common features like metabolic dysregulation, hepatic endocannabinoid system (eCBS) perturbation, and inflammation.

Purpose of the Study:

To explore the therapeutic potential of targeting the hepatic eCBS for managing CLDs.
To review the evidence for cannabis derivatives in providing hepatoprotective effects against CLDs.

Main Methods:

Review of experimental models of CLDs.
Analysis of observational studies in humans.
Evaluation of existing clinical trial data on phytocannabinoids.

Main Results:

Experimental and observational data suggest potential hepatoprotective effects of cannabis derivatives against CLDs.
Clinical trials on prominent phytocannabinoids like cannabidiol and tetrahydrocannabivarin have yielded inconclusive results.

Conclusions:

The hepatic eCBS presents a promising therapeutic target for CLDs.
Further research into less-studied phytocannabinoids and their metabolic mechanisms is needed for novel CLD therapeutics.