Angiogenesis and Multiple Sclerosis Pathogenesis: A Glance at New Pharmaceutical Approaches

Area of Science:

• Neuroscience
• Immunology
• Pathology

Background:

• Multiple sclerosis (MS) is a chronic central nervous system disease involving demyelination and axonal destruction.
• Relapsing-remitting MS, the most common form, features neurological attacks followed by recovery.
• Excessive angiogenesis is an underappreciated factor in MS pathogenesis.

Purpose of the Study:

• To review the role of angiogenesis in the onset and progression of multiple sclerosis.
• To examine the molecular mechanisms driving angiogenesis in MS.
• To discuss current and potential therapeutic strategies, emphasizing natural compounds.

Main Methods:

• Literature review of scientific articles on multiple sclerosis and angiogenesis.
• Analysis of molecular pathways involved in angiogenesis.
• Evaluation of existing and novel therapeutic approaches.

Main Results:

• Angiogenesis plays a significant role in the initiation and development of multiple sclerosis.
• Specific molecular mechanisms drive aberrant blood vessel formation in the CNS in MS.
• Current therapies have limitations, highlighting the need for novel strategies.

Conclusions:

• Targeting angiogenesis presents a promising therapeutic avenue for multiple sclerosis.
• Natural compounds offer potential as multi-target agents with neuroprotective and anti-angiogenic benefits.
• Further research into angiogenesis inhibitors and natural compounds is warranted for MS treatment.