Related Experiment Video
Updated: Aug 30, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Custom Bone Regeneration (CBR): An Alternative Method of Bone Augmentation-A Case Series Study
Daniele De Santis1, Luciano Umberto1, Donadello Dario1
1Head and Neck Department, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, 37124 Verona, Italy.
This study demonstrates that customized CAD CAM titanium meshes are a reliable method for Guided Bone Regeneration (GBR), effectively augmenting atrophic ridges for dental implants. The technique achieved significant bone volume increases with a high implant survival rate.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Dentistry
- Biomaterials in Dentistry
Background:
- Edentulous atrophic ridges present a significant challenge for oral rehabilitation with dental implants.
- Guided Bone Regeneration (GBR) is a common technique for bone augmentation, but its reliability can be influenced by materials and surgical approach.
Purpose of the Study:
- To evaluate the reliability of customized CAD CAM titanium meshes (Yxoss CBR® Reoss) for Guided Bone Regeneration (GBR).
- To assess the efficacy of this GBR technique as an alternative method for bone augmentation in patients with atrophic ridges.
Main Methods:
- A clinical study involving nine patients with ten bone defects due to edentulous atrophic ridges.
- GBR was performed using Yxoss CBR® Reoss titanium meshes combined with autogenous bone grafting and heterologous bovine bone mineral grafting.
- A "poncho technique" soft tissue approach was exclusively used for all cases, followed by mesh removal and implant surgery after a mean 9-month healing period.
Main Results:
- All ten grafted sites achieved a three-dimensional volumetric bone increase, with average horizontal gain of 6.37 mm and vertical gain of 5.95 mm.
- One site experienced titanium mesh exposure, but all sites showed successful bone augmentation without biological complications prior to implant surgery.
- Eighteen implants were placed in the grafted sites with a 100% survival rate.
Conclusions:
- The CBR procedure using Yxoss® by Reoss customized titanium meshes is a reliable and safe method for bone regeneration in horizontal, vertical, and combined bone defects.
- This technique facilitates successful implant-prosthetic restoration in patients with significant bone loss.
- The "poncho" flap approach for soft tissue management is crucial in decreasing the complication of mesh exposure.
Related Concept Videos
Bone Remodeling
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...

