Low Anterior Resection Syndrome: What Have We Learned Assessing a Large Population?

Area of Science:

• Gastroenterology and Surgical Oncology
• Epidemiology
• Patient-Reported Outcomes

Background:

• Low anterior resection syndrome (LARS) significantly impacts patients' quality of life.
• Understanding LARS prevalence in the general population is crucial for accurate assessment and management.

Purpose of the Study:

• To determine the prevalence of symptoms associated with the LARS score in a large, general population.
• To identify demographic and clinical factors associated with LARS symptoms.

Main Methods:

• A population-based study utilizing online platforms and general practitioners for data collection across Lithuania.
• 8183 participants completed the LARS score questionnaire.
• Multivariate logistic regression analysis was employed to identify risk factors.

Main Results:

• 14.2% of participants reported major LARS symptoms, and 36.4% reported minor symptoms.
• Major LARS symptoms were significantly associated with previous surgeries (71.7% in operated vs. 28.3% in non-operated).
• Neurological drug use (OR 1.6) and gynecological operations (OR 1.28) were independent risk factors for major LARS.

Conclusions:

• LARS symptoms are prevalent in the general population, influenced by factors beyond colorectal surgery.
• Age, sex, previous operations, comorbidities, and medication are key factors affecting LARS.
• These findings are vital for interpreting LARS scores and guiding preoperative treatment considerations.