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Hydrolyzed Rice Formula: An Appropriate Choice for the Treatment of Cow's Milk Allergy
Caterina Anania1, Ivana Martinelli1, Giulia Brindisi1
1Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Insights
Hydrolyzed rice-based formulas (HRFs) offer a safe and effective alternative for infants with cow
Area of Science:
- Pediatric Nutrition
- Allergy and Immunology
- Gastroenterology
Background:
- Cow's milk allergy (CMA) is prevalent in infants, causing varied symptoms.
- Dietary management for CMA includes hypoallergenic formulas.
- Extensively hydrolyzed cow's milk formulas (eHF) and amino acid-based formulas (AAF) are primary options.
Purpose of the Study:
- To review the nutritional profile of hydrolyzed rice-based formulas (HRFs).
- To evaluate the efficacy and tolerance of HRFs in infants with CMA.
- To provide an updated overview of current evidence on HRF use in pediatric CMA.
Main Methods:
- Literature review of nutritional composition of HRFs.
- Analysis of studies on HRF efficacy and tolerance in children.
- Synthesis of recent evidence regarding HRFs for CMA management.
Main Results:
- HRFs demonstrate excellent efficacy and tolerance in infants with CMA.
- HRFs appear adequate for supporting normal growth in children with CMA.
- HRFs serve as a viable alternative for those who do not tolerate or prefer other hypoallergenic formulas.
Conclusions:
- Hydrolyzed rice-based formulas are a suitable and effective option for managing cow's milk allergy in infants.
- HRFs provide adequate nutrition and support normal growth in affected children.
- Evidence supports HRFs as a valuable alternative in the dietary management of pediatric CMA.
Abstract:
Cow's milk allergy (CMA) is a common condition in the pediatric population. CMA can induce a diverse range of symptoms of variable intensity. It occurs mainly in the first year of life, and if the child is not breastfed, hypoallergenic formula is the dietary treatment. Extensively hydrolyzed cow's milk formulas (eHF) with documented hypo-allergenicity can be recommended as the first choice, while amino acid-based formulas (AAF) are recommended for patients with more severe symptoms. Hydrolyzed rice-based formulas (HRFs) are a suitable alternative for infants with CMA that cannot tolerate or do not like eHF and in infants with severe forms of CMA. In the present paper, we reviewed the nutritional composition of HRFs as well as studies regarding their efficacy and tolerance in children, and we provided an updated overview of the recent evidence on the use of HRFs in CMA. The available studies provide evidence that HRFs exhibit excellent efficacy and tolerance and seem to be adequate in providing normal growth in healthy children as well as in children with CMA.
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