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Role of Lipid-Lowering Therapy in Peripheral Artery Disease

Agastya D Belur1, Aangi J Shah2, Salim S Virani3

  • 1Division of Cardiology, University of Louisville, Louisville, KY 40202, USA.

Journal of Clinical Medicine
|August 26, 2022
PubMed

Insights

This review examines lipid-lowering therapies for atherosclerotic peripheral artery disease (PAD), a common condition affecting millions globally. It highlights the role of lipoproteins in PAD development and progression.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Pharmacology

Background:

  • Atherosclerosis is a lipoprotein-driven disease causing arterial plaque, stenosis, and thrombosis, leading to significant global cardiovascular morbidity and mortality.
  • Peripheral artery disease (PAD), atherosclerosis in the lower extremities, causes mobility loss, amputation, and critical limb ischemia, affecting 10 million in the US and 200 million worldwide.
  • Apolipoprotein B-containing lipoproteins, including LDL and remnant lipoproteins, are established contributors to atherosclerosis development and progression.

Purpose of the Study:

  • To review existing data on lipid-lowering therapies specifically for atherosclerotic peripheral artery disease (PAD).
  • To consolidate current understanding of treatment strategies targeting lipid profiles in PAD patients.

Main Methods:

  • Systematic review of published literature on lipid-lowering interventions in PAD.
  • Analysis of clinical trial data and observational studies focusing on lipid modification and PAD outcomes.

Main Results:

  • Lipid-lowering therapies, particularly those targeting LDL cholesterol, show potential in managing atherosclerosis progression in PAD.
  • Further research is needed to fully elucidate the efficacy and optimal use of various lipid-modulating agents in PAD.

Conclusions:

  • Lipid management is a critical component in addressing the burden of atherosclerotic peripheral artery disease.
  • Evidence supports the role of targeting apolipoprotein B-containing lipoproteins in PAD treatment strategies.

Keywords:
PCSK9 inhibitorsamputationatherosclerosiscritical limb ischemiaicosapent ethylinclisiranintermittent claudicationlipoproteinperipheral artery diseasestatin

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