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Related Concept Videos

Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Uterine Tubes01:16

Uterine Tubes

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The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
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In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Fertilization01:38

Fertilization

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Related Experiment Video

Updated: Aug 30, 2025

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
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Uterine Factor Infertility, a Systematic Review.

Camille Sallée1, François Margueritte2, Pierre Marquet3

  • 1Department of Gynecology and Obstetrics, Mother and Child Hospital, University Hospital Center of Limoges, 87000 Limoges, France.

Journal of Clinical Medicine
|August 26, 2022
PubMed
Summary

Uterine factor infertility (UFI) affects 2.1-16.7% of female infertility cases globally. This systematic review highlights the need for a standardized UFI definition and a patient registry to improve treatment options.

Keywords:
absolute uterine factor infertilityacquired uterine dysfunctioncongenital uterine dysfunctionnon-absolute uterine factor infertilityuterine factor infertility

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Area of Science:

  • Reproductive Medicine
  • Infertility Research
  • Gynecology

Background:

  • Uterine factor infertility (UFI) arises from uterine absence or dysfunction.
  • Current prevalence and causes of UFI remain largely uncharacterized.
  • Limited treatment options exist for women with UFI.

Purpose of the Study:

  • To conduct a worldwide systematic review to evaluate the prevalence of UFI.
  • To identify and assess the proportion of different causes contributing to UFI.
  • To highlight the need for a standardized definition and data collection for UFI.

Main Methods:

  • Systematic review conducted according to PRISMA criteria.
  • Inclusion of 188 studies for qualitative synthesis.
  • Analysis of global data on UFI prevalence and etiological factors.

Main Results:

  • UFI represents 2.1% to 16.7% of all female infertility cases.
  • Significant heterogeneity in available data regarding specific UFI causes (e.g., uterine agenesia, Asherman syndrome, adenomyosis).
  • Lack of a universally accepted definition for UFI was identified.

Conclusions:

  • A consensus definition for UFI is critically needed.
  • Establishing a national UFI patient registry is recommended.
  • Improved classification and data collection are essential for advancing UFI research and patient care.