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Diabetes without Overt Cardiac Disease Is Associated with Markers of Abnormal Repolarization: A Case-Control Study

Tomer Stahi1, Keren Kaminer2, Itay Shavit1

  • 1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6329302, Israel.

Life (Basel, Switzerland)
|August 26, 2022
PubMed

Insights

Patients with diabetes mellitus (DM) exhibit reduced Total Cosine R to T (TCRT) values, indicating cardiac repolarization abnormalities. This finding suggests potential subclinical cardiac issues in diabetic patients without known heart disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomedical Engineering

Background:

  • Diabetes mellitus (DM) patients face higher risks of atherosclerosis, microvascular complications, and fibrosis.
  • Cardiac repolarization abnormalities in DM are not well understood, despite increased arrhythmia risk.

Purpose of the Study:

  • To investigate the prevalence of abnormal T-wave morphology markers in diabetic patients without diagnosed heart disease.
  • To assess Total Cosine R to T (TCRT) and T-wave morphology dispersion (TMD) in patients with DM and impaired fasting glucose (IFG).

Main Methods:

  • Recruited 124 patients, classifying them into DM, IFG, and control groups.
  • Utilized custom software to compute TCRT and TMD from random and averaged heartbeats.
  • Compared clinical characteristics, medication use (statins, anti-diabetic drugs), and cardiac repolarization markers between groups.

Main Results:

  • Patients with DM/IFG showed significantly decreased TCRT values compared to the control group (p < 0.01).
  • No significant differences were observed in T-wave morphology dispersion (TMD) between DM/IFG and control groups.
  • DM patients were more likely to be using statins and anti-diabetic medications.

Conclusions:

  • Reduced TCRT is a common finding in diabetic patients, even without known cardiac disease.
  • Further research is needed to determine if these repolarization changes stem from subclinical atherosclerosis, diabetic cardiomyopathy, or both.

Keywords:
diabetes mellitus (DM)diabetic cardiomyopathy (DbCM)total cosine R to T (TCRT)

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