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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
276
Up-Date on Diabetic Nephropathy.
Maria Chiara Pelle1, Michele Provenzano2, Marco Busutti2
1Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Life (Basel, Switzerland)
|August 26, 2022
Summary
Diabetic kidney disease (DKD) management focuses on controlling blood sugar and pressure. Emerging drugs show promise in slowing kidney disease progression and improving cardiovascular outcomes for diabetic patients.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Background:
- Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease (ESKD) and increases cardiovascular (CV) risk.
- Diabetic nephropathy (DN) significantly raises morbidity and mortality in individuals with diabetes.
- Chronic hyperglycemia and hypertension are key risk factors for DN.
Purpose of the Study:
- To provide a comprehensive review of current and emerging treatments for diabetic kidney disease.
- To evaluate the impact of novel antidiabetic medications on kidney disease progression and CV outcomes.
- To discuss the management of both albuminuric and non-proteinuric forms of DN.
Main Methods:
- Review of current literature on diabetic kidney disease treatments.
- Analysis of clinical trial data for sodium-glucose transport protein 2 inhibitors and glucagon-like peptide-1 agonists.
- Evaluation of the role of renin-angiotensin-aldosterone system blockade.
Main Results:
- Renin-angiotensin-aldosterone system blockade benefits glomerular function and CV risk.
- New antidiabetic drugs (SGLT2 inhibitors, GLP-1 agonists) delay kidney disease progression and improve CV outcomes.
- Non-proteinuric diabetic nephropathy (NP-DN) is a recognized clinical entity.
Conclusions:
- Current treatments aim for albuminuria regression, with evolving strategies for DN management.
- Emerging therapies offer significant potential for improved renal and cardiovascular protection in diabetic patients.
- A multi-faceted approach addressing hyperglycemia, hypertension, and novel drug classes is crucial for managing DKD.
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