Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity-An Update

Area of Science:

• Oral pathology
• Virology
• Immunology

Background:

• Oral papilloma lesions are associated with human papillomavirus (HPV) infection.
• HPV types vary in risk, influencing oral papillomatosis evolution and persistence.
• Pathogenesis involves complex interactions between oral epithelial cells, immune cells, and HPV.

Purpose of the Study:

• To review pathogenic mechanisms of oral papillomatosis driven by HPV.
• To explore the role of HPV in oral cancer development (cancerization).
• To highlight the importance of molecular diagnostics and understanding local immunity for therapeutic decisions.

Main Methods:

• Literature review focusing on HPV-related oral papillomatosis.
• Analysis of pathogenic mechanisms, clinical features, and histological aspects.
• Discussion of diagnostic and therapeutic challenges.

Main Results:

• HPV infection is a primary etiological factor in oral papillomatosis.
• HPV can directly contribute to the transformation of benign lesions into malignant ones.
• Accurate molecular diagnostics are crucial for identifying HPV types and oncogenic potential.

Conclusions:

• Effective diagnosis and treatment of oral papillomatosis require understanding HPV's role and host immune response.
• Molecular diagnostics and immunological assessment are vital for guiding therapeutic strategies.
• Distinguishing between benign, potentially malignant, and malignant lesions is critical.