Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Electric Fields: Applications

Induced Electric Fields: Applications

An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimizing electrolytic ablation therapy: Effects of electrode polarization modes through in silico and in vitro studies.

Bioelectrochemistry (Amsterdam, Netherlands)·2025

Same author

Enhancement in the Therapeutic Efficacy of In Vivo BNCT Mediated by GB-10 with Electroporation in a Model of Oral Cancer.

Cells·2023

Same author

Assimilation of statistical data into turbulent flows using physics-informed neural networks.

The European physical journal. E, Soft matter·2023

Same author

Electroporation optimizes the uptake of boron-10 by tumor for boron neutron capture therapy (BNCT) mediated by GB-10: a boron biodistribution study in the hamster cheek pouch oral cancer model.

Radiation and environmental biophysics·2019

Same author

Minimally Invasive Electrochemotherapy Procedure for Treating Nasal Duct Tumors in Dogs using a Single Needle Electrode.

Radiology and oncology·2018

Same author

Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions.

Radiology and oncology·2016

Search research articles

Related Experiment Video

Updated: Aug 30, 2025

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

Bubble Formation in Pulsed Electric Field Technology May Pose Limitations.

Isaac Aaron Rodriguez Osuna¹, Pablo Cobelli^2,3, Nahuel Olaiz^2,3

¹Laboratorio de Sistemas Complejos, Departamento de Computación, Instituto de Física del Plasma, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, Argentina.

|August 26, 2022

Summary

Pulsed electric fields (PEF) enhance cell permeability but electrolysis bubbles disrupt treatment. This study models how bubbles alter electric fields and current density, revealing significant local variations that can limit PEF effectiveness.

Keywords:

current density electric field electrode coverage electroporation protocols pulse electric field

More Related Videos

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Related Experiment Videos

Last Updated: Aug 30, 2025

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Area of Science:

Biophysics
Electrochemistry
Biotechnology

Background:

Pulsed electric fields (PEF) are increasingly used to modify cell membrane permeability.
Electrolysis during PEF application generates bubbles, potentially interfering with treatment efficacy.
Understanding bubble-induced electrical variations is crucial for optimizing PEF protocols.

Purpose of the Study:

To investigate local electric field and current density variations around electrolysis bubbles formed during PEF treatment.
To develop an experimental and in silico model to predict bubble behavior and its impact on PEF.
To identify how these variations affect electroporation protocols and treatment outcomes.

Main Methods:

Experimental measurements of bubble diameter changes over time under varying electric field strengths (0.6–2 KV/cm) and conductivity (2365 μs/cm).
Development of an experimental model for bubble diameter dynamics.
In silico modeling to simulate electric field and current density distributions around bubbles, considering edge effects.

Main Results:

Electrolysis bubbles significantly increase local current density, up to four times the base value, due to edge effects.
Thermal effects from bubbles are minimal due to short pulse durations, but variations are undesirable.
Observed current increases are attributed to bubble coverage and local electric field alterations, not solely conductivity changes.

Conclusions:

Electrolysis-induced bubbles create significant local electrical anomalies that can negatively impact PEF treatments.
Bubble coverage and edge effects are key factors influencing current density and electric fields.
Further research into local conductivity and electric field variations is recommended for improved PEF applications.