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Updated: Aug 30, 2025
06:51
Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
Published on: August 21, 2018
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Acoustic Manipulation of Intraocular Particles.
Ari Leshno1,2, Avraham Kenigsberg3, Heli Peleg-Levy3
1Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel.
Micromachines
|August 26, 2022
Summary
This study introduces a novel non-invasive method using standing acoustic waves to manipulate intraocular particles, potentially preventing secondary glaucoma. Acoustic manipulation shows promise for controlling particles without damaging eye tissue.
Area of Science:
- Ophthalmology
- Biophysics
- Medical Engineering
Background:
- Dispersed particles in the anterior chamber can reduce vision and elevate intraocular pressure (IOP), leading to secondary glaucoma.
- Current treatments manage complications but lack preventive measures for particle-induced ocular issues.
Purpose of the Study:
- To introduce and evaluate a novel non-invasive method for manipulating intraocular particles using standing acoustic waves.
- To explore the potential of acoustic manipulation as a preventive strategy for secondary glaucoma.
Main Methods:
- Utilized a cylindrical acoustic resonator to generate standing acoustic waves.
- Demonstrated ex vivo manipulation of pigmentary particles within porcine eyes.
- Assessed the impact of wave intensity and duration, ruling out thermal damage via OCT and histology.
Main Results:
- Successfully manipulated intraocular particles non-invasively using standing acoustic waves.
- Confirmed no tissue damage or adverse side effects from acoustic manipulation.
- Established the feasibility of controlling particle location within the anterior chamber.
Conclusions:
- Standing acoustic waves offer a novel, non-invasive approach to manipulate intraocular particles.
- This technique has the potential to prevent secondary glaucoma by managing particle distribution and maintaining aqueous humor outflow.
- Further development could lead to a new tool for managing intraocular particle-related complications.
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