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Nationwide survey on Kawasaki disease in Japan
Insights
Kawasaki disease affects over 63,000 patients, with incidence peaking at age 1 and significant cardiac sequelae in 17.2% within a month. This nationwide survey highlights epidemic years and common treatments like aspirin.
Area of Science:
- Pediatrics
- Epidemiology
- Public Health
Background:
- Kawasaki disease is a significant pediatric illness with potential cardiac complications.
- Understanding its epidemiology is crucial for public health interventions.
Purpose of the Study:
- To statistically analyze the nationwide incidence and characteristics of Kawasaki disease.
- To report on treatment modalities and the occurrence of cardiac sequelae.
Main Methods:
- Nationwide survey data collection from July 1982 to December 1984.
- Statistical analysis of patient demographics, incidence rates, treatment, and outcomes.
Main Results:
- A total of 63,399 cases were reported, with a male to female ratio of 1.4.
- Incidence peaked at age 1 year, with epidemic years in 1979 and 1982.
- Cardiac sequelae occurred in 17.2% of patients within one month; aspirin was the most common treatment (89.8%).
Conclusions:
- Kawasaki disease exhibits epidemic patterns and a distinct age incidence peak.
- A significant proportion of patients develop cardiac sequelae, emphasizing the need for timely diagnosis and management.
Abstract:
Results of the statistical analysis of a nationwide survey of patients with Kawasaki disease diagnosed within a 2-year 6-month period, from July 1982 to December 1984, are as follows. (1) The cumulative number of patients reported by the end of 1984 was 63,399 (36,891 boys and 26,508 girls; male to female ratio 1.4). (2) There were two epidemic years, 1979 and 1982, in which the numbers of patients were more than twofold that of the previous years. (3) A curve plotted for age-specific incidence rate showed a unimodal peak at age 1 year. (4) Steroid therapy was used for 6.3% of the patients, aspirin for 89.8%, antibiotics for 57.6%, and gamma-globulin for 11.4%. (5) The proportion of sibling cases was 1.4% and that of recurrent cases was 3.9% of all cases reported. (6) The incidence of cardiac sequelae in 1 month after disease onset was 17.2%.
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