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3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
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Recent Advances in Cellulose-Based Hydrogels for Tissue Engineering Applications.

Chao Chen1, Yuewei Xi1,2, Yunxuan Weng1,2

  • 1College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.

Polymers
|August 26, 2022
PubMed
Summary
This summary is machine-generated.

Cellulose-based hydrogels offer promising biocompatible scaffolds for tissue engineering due to their excellent properties. This review explores their structure, preparation, and applications in skin, bone, and cartilage regeneration.

Keywords:
cellulosecellulose derivativecellulose-based hydrogeltissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Cellulose and its derivatives possess desirable properties like hydrophilicity, mechanical strength, biodegradability, and biocompatibility.
  • Abundant functional groups in cellulose make it a suitable precursor for synthesizing biocompatible hydrogels.
  • Recent advancements highlight the potential of cellulose-based materials in various biomedical applications.

Purpose of the Study:

  • To review the application prospects of cellulose and its derivatives-based hydrogels in biomedical tissue engineering.
  • To analyze recent research on cellulose hydrogels for tissue regeneration.
  • To summarize challenges and future directions in this field.

Main Methods:

  • Discussion of the structure and properties of cellulose, nano celluloses (NC), and cellulose derivatives.
  • Description of preparation methods for physical and chemical cellulose hydrogels.
  • Analysis of recent literature on the application of cellulose hydrogels in tissue engineering scaffolds.

Main Results:

  • Cellulose, nano celluloses (including cellulose nanocrystals (CNC), cellulose nanofibrils (CNF), and bacterial nano celluloses (BNC)), and cellulose derivatives (ethers, esters) exhibit favorable characteristics for hydrogel formation.
  • Both physical and chemical methods can be employed to prepare cellulose-based hydrogels with tunable properties.
  • Cellulose hydrogels have demonstrated significant potential as scaffolds for skin, bone, and cartilage tissue engineering.

Conclusions:

  • Cellulose-based hydrogels are versatile biomaterials with substantial potential for tissue engineering applications.
  • Further research is needed to overcome existing challenges and fully realize the clinical translation of these materials.
  • The unique properties of cellulose derivatives offer exciting avenues for developing next-generation tissue regenerative therapies.