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Mussel-Inspired Adhesive and Self-Healing Hydrogel as an Injectable Wound Dressing.

Kai-Yi Chang1, Ying-Nien Chou1, Wei-Yu Chen1

  • 1Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan.

Polymers
|August 26, 2022
PubMed
Summary

This study presents a novel injectable hydrogel inspired by mussel adhesive proteins. The temperature-sensitive NIPAAm-DAA-HA hydrogel exhibits excellent self-healing, adhesion, and antibacterial properties for advanced wound treatment.

Keywords:
N-isopropyl acrylamideadhesiondopaminehydrogelhydrophobic associationinjectable hydrogelmussel-inspiredself-healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Mussel-inspired adhesives offer unique properties for biomedical applications.
  • Developing injectable hydrogels with self-healing and adhesive capabilities is crucial for wound healing.
  • Existing wound dressings have limitations in managing deep wounds and infection.

Purpose of the Study:

  • To develop a multi-functional, injectable hydrogel with mussel-inspired adhesive and self-healing properties.
  • To create a temperature-sensitive hydrogel system for wound treatment.
  • To evaluate the hydrogel's mechanical, adhesive, self-healing, antibacterial, and drug delivery capabilities.

Main Methods:

  • Fabrication of a dual-component injectable hydrogel (NIPAAm-DAA-HA) using hydrophobic association cross-linking.
  • Incorporation of stearyl methacrylate (C18) for enhanced mechanical strength and SDS for micelle formation.
  • Utilizing dopamine acrylate (DAA) for self-healing and ferric chloride (FeCl3) as a cross-linking agent.
  • Characterization using rheology, NMR, swelling tests, compression tests, adhesion tests, self-healing assays, antibacterial tests, and in vitro drug release.

Main Results:

  • The NIPAAm-DAA-HA hydrogel formed within 7 minutes at physiological temperature (25-32 °C).
  • Enhanced mechanical properties were observed with the addition of C18 hydrophobic micelles.
  • High adhesiveness (0.0081 kg/cm²) to pig skin and significant self-healing (up to 70% in 24h) were achieved.
  • The hydrogel demonstrated good antibacterial resistance and a drug release capability of up to 8.87 μg/cm².

Conclusions:

  • The developed mussel-inspired hydrogel possesses excellent injectability, adhesion, and self-healing properties.
  • Its thermo-sensitive, antibacterial, and drug-releasing characteristics make it a promising candidate for deep wound treatment.
  • This advanced hydrogel addresses limitations of traditional wound dressings, offering improved therapeutic outcomes.