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ZnO Nanorods Coated Single-Mode-Multimode-Single-Mode Optical Fiber Sensor for VOC Biomarker Detection.

Kankan Swargiary1, Prattakorn Metem1,2, Chayapol Kulatumyotin1

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Summary
This summary is machine-generated.

This study presents a novel ZnO-coated optical fiber sensor for detecting isopropanol, a diabetes biomarker. The sensor achieved a sensitivity of 0.053 nm/%IPA vapor, showing promise for non-invasive disease detection.

Keywords:
ZnO nanorodbiomarker detectionoptical fiber sensorsurface functionalizationvolatile organic compound

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Area of Science:

  • Optoelectronics
  • Chemical Sensing
  • Biomedical Engineering

Background:

  • Diabetes mellitus is a global health concern requiring accessible diagnostic tools.
  • Volatile organic compounds (VOCs) in breath, such as isopropanol (IPA), can serve as biomarkers for diabetes.
  • Current detection methods often lack the sensitivity, selectivity, or non-invasiveness required for widespread screening.

Purpose of the Study:

  • To develop and demonstrate a ZnO-coated optical fiber sensor for detecting isopropanol (IPA) as a diabetes biomarker.
  • To optimize the sensor structure for enhanced light-matter interaction and sensitivity.
  • To evaluate the sensor's performance in detecting varying concentrations of IPA vapor.

Main Methods:

  • Fabrication of a single-mode fiber-coreless fiber-single-mode fiber (SMF-CSF-SMF) structure for enhanced multimode interference (MMI).
  • Surface functionalization of the CSF with zinc oxide (ZnO) nanorods via hydrothermal growth.
  • Numerical optimization of the CSF length for maximum coupling efficiency.
  • Experimental testing of the sensor with IPA vapor concentrations ranging from 20% to 100%.

Main Results:

  • Successful fabrication of the ZnO-coated optical fiber sensor.
  • Demonstrated detection of IPA vapor with a sensitivity of 0.053 nm/%IPA.
  • The MMI in the CSF region enhanced light interaction for improved sensing.
  • Sensor response was measured using an optical spectrometer.

Conclusions:

  • The developed ZnO-coated optical fiber sensor shows significant potential for detecting IPA, a key diabetes biomarker.
  • The SMF-CSF-SMF structure combined with ZnO nanorods offers a sensitive platform for VOC detection.
  • Future work should focus on enhancing sensor selectivity and overall sensitivity for clinical applications.