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G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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PEDV: Insights and Advances into Types, Function, Structure, and Receptor Recognition.

Feng Lin¹, Huanyu Zhang¹, Linquan Li¹

¹College of Animal Sciences, Jilin University, Changchun 130062, China.

|August 26, 2022

Summary

Porcine epidemic diarrhea virus (PEDV) causes severe piglet mortality and economic losses. This review details PEDV strains, its spike protein, and explores potential host cell receptors for virus entry.

Keywords:

PEDV receptor PEDV variant strain porcine epidemic diarrhea virus (PEDV)spike protein (S protein)

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Last Updated: Aug 30, 2025

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Published on: June 8, 2022

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization

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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

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Published on: June 9, 2017

Area of Science:

Virology
Veterinary Medicine
Molecular Biology

Background:

Porcine epidemic diarrhea virus (PEDV) is a global swine pathogen causing significant economic losses.
PEDV infection targets small intestine villous cells, leading to high mortality in piglets.
The virus's spike (S) protein is crucial for host cell entry.

Purpose of the Study:

To review the structure and strains of PEDV.
To examine the structure and function of the coronavirus S protein.
To summarize research on PEDV host cell receptors.

Main Methods:

Literature review of PEDV research.
Analysis of viral structure and protein function.
Synthesis of findings on host cell receptor identification.

Main Results:

PEDV structure and various strains are characterized.
The S protein's role in coronavirus cell entry is conserved.
Progress in identifying PEDV host cell receptors is summarized.

Conclusions:

Understanding PEDV, its S protein, and host interactions is key to control.
Further research into host cell receptors can inform antiviral strategies.
This review provides a foundation for future PEDV research.